Ethopabate (HCID 6034)

概要

Ethopabate is an amidobenzoic acid.

名称と識別子

優先名称: Ethopabate
IUPAC: methyl 4-acetamido-2-ethoxybenzoate
現地名: エトバベート
英語名: Ethopabate
分子式: C12H15NO4
分子量: 237.25

名称と別名

ETHOPABATEMethyl 4-acetamido-2-ethoxybenzoate59-06-3Benzoic acid, 4-(acetylamino)-2-ethoxy-, methyl esterDTXSID6046264DTXCID4026264F4X3L6068ORefChem:58641200-414-3MFCD00075809Methyl 4-(acetylamino)-2-ethoxybenzoateAmprol Plus (veterinary)

名称をさらに表示

エトパバート4-アセトアミド-2-エトキシ安息香酸メチルエチルパバート4-アセチルアミノ-2-エトキシ安息香酸メチルエトパベート標準品エトパベートエトパベイトエトパベイト標準品エトバベートメチル 4-アセトアミド-2-エトキシベンゾアート4-Acetamido-2-ethoxybenzoic acid, methyl esterEthopatateEthytpatateIsovaleraldehvdeEthopabate (125 mg)Ethopabate, Vetranal

ETHOPABATE [MI]NCGC00160624-01CHEBI:183844ETHOPABATE [USP MONOGRAPH]Ethyl PabateMethyl 4-acetamido-2-ethoxy-benzoateNCGC00160624-04Ethopabat

データベース識別子

CAS: 59-06-3
PubChem CID: 6034
DTXSID: DTXSID6046264
ChEMBL: CHEMBL458769
ChEBI: CHEBI:183844
UNII: F4X3L6068O
EC Number: 200-414-3
Nikkaji: J4.596I

物性

構造計算による物性

XLogP: 1.2
極性表面積: 64.6 Å²
水素結合供与体数: 1
水素結合受容体数: 4
回転可能結合数: 5
重原子数: 17
形式電荷: 0
複雑度: 280

実験および物理化学的性質

Animal Drugs · 2 件

Active Ingredients (Ethopabate) -> FDA Greenbook

Pharmaceuticals -> Animal Drugs -> Approved in Taiwan

物理化学的性質

融点: 148 · 148-151 °C
沸点: 426.1 · 426.1±35.0 °C(Predicted)
比重(密度): 1.18 · 1.180±0.06 g/cm3(Predicted)
貯蔵温度: Sealed in dry,Room Temperature
溶解性: 50 mg/mL · DMSO: 50 mg/mL (210.75 mM)
外見: A solid
酸解離定数(Pka): 14.12 · 14.12±0.70(Predicted)
色: White to off-white
Merck: 13 · 13,3781
主な用途: 法医学と毒物学医薬品（低分子化合物）
InChI: InChI=1S/C12H15NO4/c1-4-17-11-7-9(13-8(2)14)5-6-10(11)12(15)16-3/h5-7H,4H2,1-3H3,(H,13,14)
InChIKey: GOVWOKSKFSBNGD-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(NC(C)=O)C=C1OCC
CAS データベース: 59 · 59-06-3(CAS DataBase Reference)
EPAの化学物質情報: Ethopabate (59-06-3)

化学的性質

化学的特性White to Off-White Solid

安全と法規制

GHS分類

GHS Classification · 5 件

This chemical does not meet GHS hazard criteria for 2.1% (1 of 48) of reports.

Warning

H302 (95.8%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory InformationChemical: Benzoic acid, 4-(acetylamino)-2-ethoxy-, methyl ester

Hazard Classes and CategoriesAcute Tox. 4 (95.8%)

安全データ

wgk: 3
hs_code: 2924296000
risk_code: 22
hazard_code: Xn
Hazard Classifications: Acute Tox. 4 OralEye Irrit. 2
ストレージクラス: 11 - Combustible Solids

化学と産業

薬理情報

ATC CodeQP - Antiparasitic products, insecticides and repellents

MeSH Pharmacological ClassificationAgents useful in the treatment or prevention of COCCIDIOSIS in man or animals.

用途と製造

Use Classification · 2 件

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Pharmaceuticals -> Animal Drugs -> Approved in Taiwan

応用分野 · 4 件

用途動物用医薬品定量用の標準品。ニワトリ、ブロイラーに用いる飼料添加物。

用途飼料添加用抗菌剤。

説明Ethopabate is a veterinary drug belonging to the class of antibiotics which contains an arylamide with a phenyl ring, a monocyclic aromatic hydrocarbon, and is a very safe drug used for the prophylaxis and treatment of coccidiosis in chickens. It has anticoccidial activity, especially against the intestinal form, and lacks activity against E. tenella of the cecum worm. The drug is a competitor of PABA, which is absorbed by the parasite and interferes with folate synthesis. It has good activity against E. acervulina and some strains of E. maxima and E. brunette. It is used only in combination with amprolium, first at a concentration of 4 ppm and later at a concentration of 40 ppm.This drug reaches peak activity on day 4 of the cycle.

使用A supplementary drug that improves the coccidiostatic effect of nicarbazin and amprolium in order to cure coccidiosis in chickens.