Trifluoroacetic acid → [6-(2-Fluoro-phenyl)-pyridazin-3-yloxy]-acetic acid

HRID 1931381ノート

反応式

HRID 1931381 の反応式
C([O:5][C:6](=[O:22])[CH2:7][O:8][C:9]1[N:10]=[N:11][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[CH:13][CH:14]=1)(C)(C)C.C(O)(C(F)(F)F)=O>>[F:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:12]1[N:11]=[N:10][C:9]([O:8][CH2:7][C:6]([OH:22])=[O:5])=[CH:14][CH:13]=1

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 68537532[6-(2-Fluoro-phenyl)-pyridazin-3-yloxy]-acetic acid tert-butyl ester

生成物 1

HCID 68537815[6-(2-Fluoro-phenyl)-pyridazin-3-yloxy]-acetic acid

実験手順

To the crude [6-(2-fluoro-phenyl)-pyridazin-3-yloxy]-acetic acid tert -butyl ester obtained in step (b) 5 ml of 90% aqueous TFA were added, and the mixture was allowed to stand at room temperature overnight. After evaporation, a sodium hydrogencarbonate solution was added, and the solution extracted with ethyl acetate. The aqueous phase was acidified to pH=4 and extracted with ethyl acetate. The combined extracts were dried and evaporated. Yield: 20 mg.

後処理

  1. customAfter evaporation
  2. additiona sodium hydrogencarbonate solution was added
  3. extractionthe solution extracted with ethyl acetate
  4. extractionextracted with ethyl acetate
  5. customThe combined extracts were dried
  6. customevaporated

出典と根拠

ORDレコード
ord-1d17238563f544ae8dc5ec20c71587ec
出典データセット
uspto-grants-2012_05
特許番号
US08188291B2

反応ノート

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