Trifluoroacetic acid → (6-Bromo-pyridazin-3-yloxy)-acetic acid

HRID 1931384ノート

反応式

HRID 1931384 の反応式
C([O:5][C:6](=[O:16])[CH2:7][O:8][C:9]1[N:10]=[N:11][C:12]([Br:15])=[CH:13][CH:14]=1)(C)(C)C.C(O)(C(F)(F)F)=O>>[Br:15][C:12]1[N:11]=[N:10][C:9]([O:8][CH2:7][C:6]([OH:16])=[O:5])=[CH:14][CH:13]=1

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 86638119(6-Bromo-pyridazin-3-yloxy)-acetic acid tert-butyl ester

生成物 1

HCID 86638120(6-Bromo-pyridazin-3-yloxy)-acetic acid

実験手順

To the crude (6-bromo-pyridazin-3-yloxy)-acetic acid tert-butyl ester obtained in step (a) 5 ml of 90% aqueous TFA were added, and the mixture was allowed to stand at room temperature for 3 h. After evaporation, a sodium hydrogencarbonate solution was added, and the solution extracted with ethyl acetate. The aqueous phase was acidified to pH=4 and extracted with ethyl acetate. The combined extracts were dried and evaporated. Yield: 147 mg.

後処理

  1. customAfter evaporation
  2. additiona sodium hydrogencarbonate solution was added
  3. extractionthe solution extracted with ethyl acetate
  4. extractionextracted with ethyl acetate
  5. customThe combined extracts were dried
  6. customevaporated

出典と根拠

ORDレコード
ord-f0787ce48fa44885af4b06184557e744
出典データセット
uspto-grants-2012_05
特許番号
US08188291B2

反応ノート

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