HCID 68535124、化合物 → HCID 59152287、化合物
反応式
[O:1]([C:8]1[N:13]=[CH:12][C:11]([CH:14]=[CH:15][C:16]([N:18]2[CH2:23][CH2:22][NH:21][C:20](=[O:24])[CH2:19]2)=[O:17])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd].CO>[O:1]([C:8]1[N:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16]([N:18]2[CH2:23][CH2:22][NH:21][C:20](=[O:24])[CH2:19]2)=[O:17])=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
10 mg of 5% palladium on carbon were added to a solution of 142 mg (0.4 mmol) of 4-[3-(6-phenoxy-pyridin-3-yl)-acryloyl]-piperazin-2-one in 15 ml of methanol, and the reaction mixture was hydrogenated at atmospheric pressure and room temperature for 12 h. The mixture was filtered and evaporated. The product was purified by preparative RP HPLC eluting with a gradient of 0 to 100% acetonitrile in water (+0.01% TFA). After lyophilization, the product was obtained as a solid. Yield: 87 mg.