Sodium Hydroxide → 3-[6-(2-Fluoro-phenyl)-pyridin-3-yl]-propionic acid

HRID 1931419ノート

反応式

HRID 1931419 の反応式
C([O:3][C:4](=[O:20])[CH2:5][CH2:6][C:7]1[CH:8]=[N:9][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[F:19])=[CH:11][CH:12]=1)C.[OH-].[Na+]>C(O)C>[F:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[C:10]1[N:9]=[CH:8][C:7]([CH2:6][CH2:5][C:4]([OH:20])=[O:3])=[CH:12][CH:11]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 68537058Ethyl 3-[6-(2-fluorophenyl)pyridin-3-yl]propanoate

生成物 1

HCID 685351183-[6-(2-Fluoro-phenyl)-pyridin-3-yl]-propionic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
47.5 °C

実験手順

11.5 g (0.042 mol) of 3-[6-(2-fluoro-phenyl)-pyridin-3-yl]-propionic acid ethyl ester were dissolved in 230 ml ethanol, 7.7 ml of a 32% sodium hydroxide solution were added, and the mixture stirred at 45 to 50° C. for 1 h. After evaporation to dryness, the remaining solid was taken up in 100 ml of water, the pH was adjusted to 2.5 to 3 with 2 N hydrochloric acid, and the precipitated product was filtered off with suction. The solid was rinsed with water and dried. Yield 10.0 g.

後処理

  1. customAfter evaporation to dryness
  2. filtrationthe precipitated product was filtered off with suction
  3. washThe solid was rinsed with water
  4. customdried

出典と根拠

ORDレコード
ord-893de52d6fb14e1893939aa08c916282
出典データセット
uspto-grants-2012_05
特許番号
US08188291B2

反応ノート

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