Hydrochloric Acid → 3-(4-Bromothiophen-2-yl)acrylic acid

HRID 1931440ノート

反応式

HRID 1931440 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=O)[S:5][CH:6]=1.C(O)(=O)[CH2:10][C:11]([OH:13])=[O:12].N1CCCCC1.Cl>N1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:10][C:11]([OH:13])=[O:12])[S:5][CH:6]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 867Malonic AcidHCID 8082PiperidineHCID 877924-Bromothiophene-2-carbaldehyde

生成物 1

HCID 27744523-(4-Bromothiophen-2-yl)acrylic acid

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

25 g (131 mmol) of 4-bromo-thiophene-2-carbaldehyde were dissolved in 180 ml of pyridine, and 16.34 g (157 mmol) of malonic acid and 1.11 g (13.1 mmol) of piperidine were added. The reaction mix was boiled under reflux for 6 h. After cooling to room temperature, the mixture was poured onto a mixture of ice and concentrated hydrochloric acid. The precipitated product was isolated by filtration. Yield: 21.15 g.

後処理

  1. additionThe reaction mix
  2. temperatureunder reflux for 6 h
  3. customThe precipitated product was isolated by filtration

出典と根拠

ORDレコード
ord-1c627d4745b24bd2a8a83ed4d2c46546
出典データセット
uspto-grants-2012_05
特許番号
US08188291B2

反応ノート

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