Sodium hydride → HCID 68536693、化合物

HRID 1931459ノート

反応式

HRID 1931459 の反応式
[H-].[Na+].[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.[C:17]([O:21][C:22](=[O:38])[CH2:23]OC1C=NC(C2C=CC=CC=2F)=CC=1)([CH3:20])([CH3:19])[CH3:18].C(OC(=O)CBr)(C)(C)C>CN(C=O)C>[C:17]([O:21][C:22](=[O:38])[CH2:23][O:16][C:13]1[CH:14]=[N:15][C:10]([C:7]2[CH:6]=[CH:5][C:4]([F:3])=[CH:9][CH:8]=2)=[CH:11][CH:12]=1)([CH3:20])([CH3:19])[CH3:18]

参加物

6

反応物 4

HCID 24758Sodium hydrideHCID 79177tert-Butyl bromoacetateHCID 463127886-(4-Fluorophenyl)pyridin-3-OLHCID 68536675[6-(2-Fluoro-phenyl)-pyridin-3-yloxy]-acetic acid tert-butyl ester

生成物 1

HCID 68536693HCID 68536693、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

119 mg (2.72 mmol) of sodium hydride (55% in mineral oil) were added to 430 mg (2.27 mmol) of 6-(4-fluoro-phenyl)-pyridin-3-ol (prepared analogously as described in Example 76(a) to (d)) in 10 ml of DMF, and the mixture was stirred at room temperature for 60 min. Then 532 mg (2.72 mmol) of bromoacetic acid tert-butyl ester were added, and the reaction mixture was stirred at room temperature for 3 h. After evaporation, water and ethyl acetate were added. The organic phase was separated, dried, and evaporated. Yield: 433 mg.

後処理

  1. customprepared analogously
  2. stirringthe reaction mixture was stirred at room temperature for 3 h
  3. customAfter evaporation, water and ethyl acetate
  4. additionwere added
  5. customThe organic phase was separated
  6. customdried
  7. customevaporated

出典と根拠

ORDレコード
ord-fdd0f3aced614d0a8afb922b1ea14767
出典データセット
uspto-grants-2012_05
特許番号
US08188291B2

反応ノート

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