Tert-butyl 3-oxopyrrolidine-1-carboxylate → Tert-butyl 3-(3-chloro-4-fluorophenyl)-3-hydroxypyrrolidine-1-carboxylate

HRID 1931861

反応式

HRID 1931861 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[C:4]([Cl:9])[CH:3]=1.[Mg].[C:11]([N:18]1[CH2:22][CH2:21][C:20](=[O:23])[CH2:19]1)([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12]>O1CCCC1>[Cl:9][C:4]1[CH:3]=[C:2]([C:20]2([OH:23])[CH2:21][CH2:22][N:18]([C:11]([O:13][C:14]([CH3:16])([CH3:15])[CH3:17])=[O:12])[CH2:19]2)[CH:7]=[CH:6][C:5]=1[F:8]

参加物

5

反応物 3

HCID 471360Tert-butyl 3-oxopyrrolidine-1-carboxylateHCID 35430654-Bromo-2-chloro-1-fluorobenzeneHCID 5462224Magnesium

生成物 1

HCID 67402987Tert-butyl 3-(3-chloro-4-fluorophenyl)-3-hydroxypyrrolidine-1-carboxylate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Preparation according to Preparation 5: 4-bromo-2-chloro-1-fluorobenzene (4.0 g, 19.1 mmol), dry tetrahydrofuran (50 mL), magnesium turnings (0.5 g, 21.0 mmol) and 1-N-boc-3-pyrrolidinone (3.89 g, 21.0 mmol). Yield: 1.65 g. MS m/z (rel. intensity, 70 eV) 315 (M+, 1), 259 (50), 214 (63), 157 (44), 57 (bp).

後処理

  1. customPreparation
  2. customaccording to Preparation 5

出典と根拠

ORDレコード
ord-10ab20ed843a43569beb18c4b377f1a5
出典データセット
uspto-grants-2012_05
特許番号
US08188301B2

関連ノート

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