Trifluoroacetic acid → 3-(2,3-Dichlorophenyl)pyrrolidin-3-ol

HRID 1931879

反応式

HRID 1931879 の反応式
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1([OH:21])[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]1.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1([OH:21])[CH2:13][CH2:12][NH:11][CH2:10]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86643429tert-Butyl 3-(2,3-dichlorophenyl)-3-hydroxypyrrolidin-1-carboxylate

生成物 1

HCID 635858853-(2,3-Dichlorophenyl)pyrrolidin-3-ol

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Preparation according to Preparation 2: tert-Butyl 3-(2,3-dichlorophenyl)-3-hydroxypyrrolidin-1-carboxylate (1.23 g, 3.7 mmol), dichloromethane (20 mL), trifluoroacetic acid (3 mL). Stirred for 0.5 h. Purification by HPLC on Waters OBD C18, 5 μm (MeOH/33 mM NH3, 20:80 to 0:100). Yield: 0.35 g. MS m/z (rel. intensity, 70 eV) 233 (M+, 6), 231 (M+, 10), 198 (32), 196 (bp), 75 (37), 56 (27).

後処理

  1. customPreparation
  2. customaccording to Preparation 2
  3. customPurification by HPLC on Waters OBD C18, 5 μm (MeOH/33 mM NH3, 20:80 to 0:100)

出典と根拠

ORDレコード
ord-7573fcd9f8aa4b12ae8d83edc94db375
出典データセット
uspto-grants-2012_05
特許番号
US08188301B2

関連ノート

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