HCID 18738443、化合物 → HCID 18738434、化合物
反応式
[N:1]1([S:7]([CH2:10][C@H:11]([CH3:22])[C:12]([O:14]CC2C=CC=CC=2)=[O:13])(=[O:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>[Pd]>[N:1]1([S:7]([CH2:10][C@H:11]([CH3:22])[C:12]([OH:14])=[O:13])(=[O:9])=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1参加物
3
実験手順
A 100 mL Fisher/Porter vessel was charged with 1 g of benzyl 3-(1-piperidinyl)sulfonyl-2(R)-methylpropionate 30 mL MeOH and a catalytic amount of 10% Pd—C. The reaction was hydrogenated at 50 psi for 3 hours. After filtration through Celite and concentration in vacuo of 3-(1-piperidinyl)sulfonyl-2(R)-methylpropionic acid was isolated in quantitive yield.
後処理
- filtrationAfter filtration
- concentrationthrough Celite and concentration in vacuo of 3-(1-piperidinyl)sulfonyl-2(R)-methylpropionic acid
- customwas isolated in quantitive yield
出典と根拠
- ORDレコード
- ord-dcef4994de94407c8aed218d4fcaf97a
- 出典データセット
- uspto-grants-2002_05
- 特許番号
- US06384036B1
反応ノート
読み込み中…