Z-L-Dap(boc)-OL → (S)-tert-Butyl (2-amino-3-hydroxypropyl)carbamate

HRID 1934685ノート

反応式

HRID 1934685 の反応式
C(OC([NH:11][C@@H:12]([CH2:15][NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][OH:14])=O)C1C=CC=CC=1>[Pd].CO.O1CCOCC1>[NH2:11][C@@H:12]([CH2:15][NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][OH:14]

参加物

5

反応物 1

HCID 10734767Z-L-Dap(boc)-OL

生成物 1

HCID 10702853(S)-tert-Butyl (2-amino-3-hydroxypropyl)carbamate収率 105.8%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

10% Palladium on activated carbon (10 mg) was added to a solution of (S)-2-(benzyloxycarbonylamino)-3-(tert-butoxycarbonylamino)propanol (920 mg) in methanol (10 mL) and dioxane (1 mL). The mixture was stirred under hydrogen atmosphere (3.5 atm) for one and a half days at ambient temperature. The catalyst was removed by filtration and the filtrate was concentrated in vacuo. The residue was dissolved in ethyl acetate, dried over magnesium sulfate, and concentrated in vacuo to give (S)-2-amino-3-(tert-butoxycarbonylamino)propanol (571 mg) as a white solid substance.

後処理

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated in vacuo
  3. dissolutionThe residue was dissolved in ethyl acetate
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-2da21c72f9204bdcb25e706b8670a32d
出典データセット
uspto-grants-2002_05
特許番号
US06384080B1

反応ノート

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