Triphenylphosphine → 3-[3-(1-Triphenylmethyl-imidazol-4-yl)-propyl]-5-methyl-5-naphthalen-1-yl-imidazolidin-2,4-dione

HRID 1934812ノート

反応式

HRID 1934812 の反応式
[CH3:1][C:2]1([C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11][CH:10]=2)[NH:6][C:5](=[O:7])[NH:4][C:3]1=[O:8].[C:19]1([C:25]([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[N:26]2[CH:30]=[C:29]([CH2:31][CH2:32][CH2:33]O)[N:28]=[CH:27]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O1CCCC1>[C:41]1([C:25]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)([C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[N:26]2[CH:30]=[C:29]([CH2:31][CH2:32][CH2:33][N:4]3[C:3](=[O:8])[C:2]([CH3:1])([C:9]4[C:18]5[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=5)[CH:12]=[CH:11][CH:10]=4)[NH:6][C:5]3=[O:7])[N:28]=[CH:27]2)[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1

参加物

5

反応物 3

HCID 11776TriphenylphosphineHCID 2405155-Methyl-5-(naphthalen-1-yl)imidazolidine-2,4-dioneHCID 108328403-(1-Trityl-1H-imidazol-4-YL)propan-1-OL

生成物 1

HCID 224668503-[3-(1-Triphenylmethyl-imidazol-4-yl)-propyl]-5-methyl-5-naphthalen-1-yl-imidazolidin-2,4-dione収率 80%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

0.60 g(2.5 mmol) of 5-methyl-5-naphthalen-1-yl-imidazolidin-2,4-dione prepared in Preparation 1, 1.02 g(2.76 mmol) of 3-(1-triphenylmethyl-imidazol-4-yl)-propanol and 0.87 g(3.3 mmol) of triphenylphosphine (Ph3P) were dissolved in 50 ml of tetrahydrofuran. 0.52 ml(3.3 mmol) of diethylazodicarboxylate[DEAD] was added thereto and the resulting solution was stirred for 24 hours. Tetrahydrofuran was removed under reduced pressure and the residue was subjected to chromatography using ethyl acetate the eluent to obtain 1.17 g(Yield: 80%) of the title compound.

後処理

  1. customTetrahydrofuran was removed under reduced pressure

出典と根拠

ORDレコード
ord-79a1f4b2a9b14750a3a80e5c5b531252
出典データセット
uspto-grants-2002_05
特許番号
US06384061B1

反応ノート

読み込み中…