2-(2,2,2-Trifluoroethoxy)-5-chlorobenzylamine hydrochloride → (2-(2,2,2-Trifluoroethoxy)phenyl)methanamine

HRID 1935444ノート

反応式

HRID 1935444 の反応式
Cl.[F:2][C:3]([F:16])([F:15])[CH2:4][O:5][C:6]1[CH:13]=[CH:12][C:11](Cl)=[CH:10][C:7]=1[CH2:8][NH2:9]>C(O)C.[OH-].[OH-].[Pd+2]>[F:2][C:3]([F:15])([F:16])[CH2:4][O:5][C:6]1[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=1[CH2:8][NH2:9]

参加物

4

反応物 1

HCID 224645182-(2,2,2-Trifluoroethoxy)-5-chlorobenzylamine hydrochloride

生成物 1

HCID 16772829(2-(2,2,2-Trifluoroethoxy)phenyl)methanamine

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

A solution of 2-(2,2,2-trifluoroethoxy)-5-chlorobenzylamine hydrochloride (650 mg) in ethanol (200 mL) containing 20% Pd(OH)2/C (1 g) was hydrogenated at 50 psi for 4 h. The catalyst was removed via filtration through Celite and the filtrate then evaporated to dryness to give the title compound as a white powder: 1H NMR (CD3OD) δ7.47 (m, 2H), 7.19 (m, 2H), 4.69 (q, J=8.4 Hz, 2H), 4.16 (s, 2H).

後処理

  1. customThe catalyst was removed via filtration through Celite
  2. customthe filtrate then evaporated to dryness

出典と根拠

ORDレコード
ord-442888d82f8f4260a3044ebeba3c36ad
出典データセット
uspto-grants-2002_05
特許番号
US06387911B1

反応ノート

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