Citric Acid → (r)-3-Triisopropylsilyloxybutyric acid

HRID 1935563ノート

反応式

HRID 1935563 の反応式
[CH:1]([Si:4]([CH:17]([CH3:19])[CH3:18])([CH:14]([CH3:16])[CH3:15])[O:5][C@H:6]([CH3:13])[CH2:7][C:8]([O:10]CC)=[O:9])([CH3:3])[CH3:2].[OH-].[Li+].C(O)(=O)CC(CC(O)=O)(C(O)=O)O>O1CCCC1.O>[CH:17]([Si:4]([CH:1]([CH3:3])[CH3:2])([CH:14]([CH3:16])[CH3:15])[O:5][C@H:6]([CH3:13])[CH2:7][C:8]([OH:10])=[O:9])([CH3:18])[CH3:19]

参加物

5

反応物 3

HCID 311Citric AcidHCID 3939Lithium HydroxideHCID 54538409Ethyl (r)-(-)-3-triisopropylsilyloxybutyrate

生成物 1

HCID 14084664(r)-3-Triisopropylsilyloxybutyric acid

試薬・触媒・溶媒 1

HCID 21881883Oxolane--water (1/1)溶媒

実験手順

0.0755 mol (21.78 g) of the product from stage 1 is stirred at 60° C. for 5 days in 1.51 liters of a 0.01 molar lithium hydroxide solution in a tetrahydrofuran/water 1:1 mixture. The mixture is acidified with aqueous citric acid and the product is extracted with ethyl acetate. The organic phase is washed with water, dried over sodium sulfate and concentrated under reduced pressure.

後処理

  1. extractionthe product is extracted with ethyl acetate
  2. washThe organic phase is washed with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-5772b7c0795646cd87e32e73e3cb706d
出典データセット
uspto-grants-2002_05
特許番号
US06387934B1

反応ノート

読み込み中…