Trifluoroacetic acid → 6-Bromo-1,2,3,4-tetrahydro-3-quinolinamine
反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH2:7][CH:6]([NH:12]C(=O)OC(C)(C)C)[CH2:5]2.FC(F)(F)C(O)=O>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH2:7][CH:6]([NH2:12])[CH2:5]2参加物
4
実験手順
To a solution of (6-Bromo-1,2,3,4-tetrahydro-3-quinolinyl)carbamic acid, 1,1-dimethylethyl ester (652 mg, 2 mmol) in dichloromethane at RT under argon was added trifluoroacetic acid (1 mL). After 3 hours, the mixture was concentrated. Chloroform (10 mL) was added and concentrated again in vacuo to afford the title compound (1 g), an oil, which was used without further purification. MS; M(+H)+=227.
後処理
- concentrationthe mixture was concentrated
- additionChloroform (10 mL) was added
- concentrationconcentrated again in vacuo
出典と根拠
- ORDレコード
- ord-22b7c889761f4e31b5c5e5a92dd0735a
- 出典データセット
- uspto-grants-2002_05
- 特許番号
- US06387926B1
反応ノート
読み込み中…