Triphosgene → HCID 22462550、化合物

HRID 1936718ノート

反応式

HRID 1936718 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[C:16]3[C:11](=CC=C[CH:15]=3)[C:10]([NH2:17])=[CH:9][CH:8]=2)=[CH:3][CH:2]=1.[NH2:18][C:19]1[CH:20]=[C:21]2[C:25](=[CH:26][CH:27]=1)[NH:24][CH:23]=[C:22]2[CH:28]1[CH2:33][CH2:32][N:31]([CH3:34])[CH2:30][CH2:29]1.Cl[C:36](Cl)([O:38]C(=O)OC(Cl)(Cl)Cl)Cl>C(N(CC)CC)C>[CH3:34][N:31]1[CH2:32][CH2:33][CH:28]([C:22]2[C:21]3[C:25](=[CH:26][CH:27]=[C:19]([NH:18][C:36]([NH:17][C:10]4[CH:9]=[CH:8][C:7]([C:4]5[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=5)=[C:16]([CH3:15])[CH:11]=4)=[O:38])[CH:20]=3)[NH:24][CH:23]=2)[CH2:29][CH2:30]1

参加物

5

反応物 3

HCID 94429TriphosgeneHCID 108570124-(Pyridin-4-yl)naphth-1-ylamineHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

生成物 1

HCID 22462550HCID 22462550、化合物

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

The title compound was prepared in a similar manner to Example 1 from 3-methyl-4-(pyridin-4-yl)aniline (prepared as for D3 from 4-bromo-3-methylaniline) (0.17 g, 0.9 mmole), 5-amino-3-(1-methylpiperdin-4-yl)-1H-indole (D2, 0.17 g, 0.75 mmole), triphosgene (0.10 g, 0.35 mmole) and triethylamine (0.07 ml). This was obtained as a buff powder (0.11 g).

出典と根拠

ORDレコード
ord-bdc34677bf2a4cc1aaf411b119ecfb89
出典データセット
uspto-grants-2002_05
特許番号
US06391891B1

反応ノート

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