Sodium Hydroxide → sodium [6,7,8,9-tetrahydro-6-[((2S)-2-hydroxy-3-phenoxypropyl)amino]-5H-benzocyclohepten-1-yloxy]acetate

HRID 1936972ノート

反応式

HRID 1936972 の反応式
C([O:3][C:4]([CH2:6][O:7][C:8]1[C:13]2[CH2:14][CH2:15][CH2:16][CH:17]([NH:19][CH2:20][C@H:21]([OH:30])[CH2:22][O:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:18][C:12]=2[CH:11]=[CH:10][CH:9]=1)=[O:5])C.[OH-].[Na+:32]>CO>[OH:30][C@H:21]([CH2:22][O:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[CH2:20][NH:19][CH:17]1[CH2:16][CH2:15][CH2:14][C:13]2[C:8]([O:7][CH2:6][C:4]([O-:5])=[O:3])=[CH:9][CH:10]=[CH:11][C:12]=2[CH2:18]1.[Na+:32]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 70131462(2S)-1-[(1-ethoxycarbonylmethoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)amino]-3-phenoxy-2-propanol

生成物 1

HCID 86584188sodium [6,7,8,9-tetrahydro-6-[((2S)-2-hydroxy-3-phenoxypropyl)amino]-5H-benzocyclohepten-1-yloxy]acetate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of (2S)-1-[(1-ethoxycarbonylmethoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)amino]-3-phenoxy-2-propanol (103 mg) in methanol (5.0 ml) and 0.1N sodium hydroxide aqueous solution (2.5 ml) was stirred for 22 hours and evaporated in vacuo. The residue was triturated in diethyl ether and the precipitated powder was collected by filtration to afford sodium [6,7,8,9-tetrahydro-6-[((2S)-2-hydroxy-3-phenoxypropyl)amino]-5H-benzocyclohepten-1-yloxy]acetate (98 mg) as a pale yellow powder.

後処理

  1. customevaporated in vacuo
  2. customThe residue was triturated in diethyl ether
  3. filtrationthe precipitated powder was collected by filtration

出典と根拠

ORDレコード
ord-ca2fdbd3cfa04b9db071205cd19d7277
出典データセット
uspto-grants-2002_05
特許番号
US06391915B2

反応ノート

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