Sodium Hydroxide → (+/-)-4-(1-Dodecenyl)-alpha-phenyl-1H-pyrazole-1-acetic acid

HRID 1938712ノート

反応式

HRID 1938712 の反応式
[OH-].[Na+].[CH:3]([C:15]1[CH:16]=[N:17][N:18]([CH:20]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:21]([O:23]CC)=[O:22])[CH:19]=1)=[CH:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]>C(O)C>[CH:3]([C:15]1[CH:16]=[N:17][N:18]([CH:20]([C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:21]([OH:23])=[O:22])[CH:19]=1)=[CH:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 54242059Ethyl (+/-)-4-(1-dodecenyl)-alpha-phenyl-1H-pyrazole-1-acetate

生成物 1

HCID 53719716(+/-)-4-(1-Dodecenyl)-alpha-phenyl-1H-pyrazole-1-acetic acid収率 105.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Solid NaOH (6.72 g, 168 mmol) was added to a solution of ethyl (±)-4-(1-dodecenyl)-α-phenyl-1H-pyrazole-1-acetate (44.41 g, 112 mmol) in 500 mL 95% ethanol. The resulting yellow solution was stirred for 1 hour and then concentrated in vacuo. The residue was partitioned between water and ether, the aqueous layer was acidified with concentrated HCl and extracted with ethyl acetate. The ethyl acetate layer was dried over MgSO4, filtered, and concentrated to give a yellow oil (43.4 g) used without further purification.

後処理

  1. concentrationconcentrated in vacuo
  2. customThe residue was partitioned between water and ether
  3. extractionextracted with ethyl acetate
  4. dry with materialThe ethyl acetate layer was dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-83223d66c9a14224ac21f8bf52190a93
出典データセット
uspto-grants-1997_12
特許番号
US05693657

反応ノート

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