1-Methyl-6-nitroindoline → 1-methyl-2,3-dihydro-1H-indol-6-amine
反応式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([N+:11]([O-])=O)[CH:9]=2)[CH2:4][CH2:3]1>CO.[Pd]>[NH2:11][C:8]1[CH:9]=[C:10]2[C:5]([CH2:4][CH2:3][N:2]2[CH3:1])=[CH:6][CH:7]=1参加物
4
実験手順
1-Methyl-6-nitroindoline (0.9 g) was hydrogenated at 40 psi in methanol (100 ml) containing 10% palladium on carbon (0.9 g). The reaction mixture was filtered then evaporated and the residue was purified by column chromatography on silica using hexane→50% ethyl acetate/hexane to afford the title compound (0.62 g).
後処理
- filtrationThe reaction mixture was filtered
- customthen evaporated
- customthe residue was purified by column chromatography on silica
出典と根拠
- ORDレコード
- ord-bc382abe11ab4427b78b010cda2a1519
- 出典データセット
- uspto-grants-1997_12
- 特許番号
- US05696110
反応ノート
読み込み中…