1-Isothiocyanato-3-(trifluoromethyl)benzene → N-(3-(trifluoromethyl)phenyl)-N'-(2-methoxy-5-(trifluoromethyl)phenyl) thiourea

HRID 1939283

反応式

HRID 1939283 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([N:9]=[C:10]=[S:11])[CH:6]=[CH:7][CH:8]=1.[CH3:14][O:15][C:16]1[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][C:17]=1[NH2:18]>C1(C)C=CC=CC=1>[F:13][C:2]([F:12])([F:1])[C:3]1[CH:4]=[C:5]([NH:9][C:10]([NH:18][C:17]2[CH:19]=[C:20]([C:23]([F:25])([F:26])[F:24])[CH:21]=[CH:22][C:16]=2[O:15][CH3:14])=[S:11])[CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 1372321-Isothiocyanato-3-(trifluoromethyl)benzeneHCID 6006372-Methoxy-5-(trifluoromethyl)aniline

生成物 1

HCID 54197929N-(3-(trifluoromethyl)phenyl)-N'-(2-methoxy-5-(trifluoromethyl)phenyl) thiourea収率 51%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

3-(trifluoromethyl)phenyl isothiocyanate in toluene (0.76 ml, 5.0 mmol) was added to a solution of 2-methoxy-5-(trifluoromethyl)aniline in toluene (10 ml). The resulting reaction mixture was stirred at RT overnight and the product was subsequently filtered off. 1.00 g (51%) of the title compound was isolated.

後処理

  1. customThe resulting reaction mixture
  2. filtrationthe product was subsequently filtered off

出典と根拠

ORDレコード
ord-0da55e70336c4445bca4d21c00860d8f
出典データセット
uspto-grants-1997_12
特許番号
US05696138

関連ノート

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