Ethanol → Ethyl 5-ethoxy-4,5-dihydro-1,2-oxazole-3-carboxylate
反応式
[CH2:1]([O:3][CH:4]=[CH:5][C:6](=O)[C:7]([OH:9])=[O:8])[CH3:2].Cl.[NH2:12][OH:13].O.[CH2:15](O)[CH3:16]>>[CH2:1]([O:3][CH:4]1[O:13][N:12]=[C:6]([C:7]([O:9][CH2:15][CH3:16])=[O:8])[CH2:5]1)[CH3:2]参加物
5
実験手順
17.22 g of 4-ethoxy-2-oxo-3-butenoic acid prepared according to the method of L. Tietze et al. (Lutz-F. Tietze, Heinrich Meier and Edgar Voss, Synthesis 1988, 274) are dissolved in 50 ml of anhydrous ethanol, and 7.34 g of hydroxylamine hydrochloride is added thereto, and the mixture is stirred at room temperature for 4 hours. The reaction mixture is added with water and extracted with methylene chloride. The organic layer is washed with water, dried, and evaporated. The resulting residue is distilled under reduced pressure to yield 14.3 g of ethyl 5-ethoxyisoxazoline-3carboxylate. (yield 76%)
後処理
- customTietze et al. (Lutz-F. Tietze, Heinrich Meier and Edgar Voss, Synthesis 1988, 274)
- extractionextracted with methylene chloride
- washThe organic layer is washed with water
- customdried
- customevaporated
- distillationThe resulting residue is distilled under reduced pressure
出典と根拠
- ORDレコード
- ord-f84e38c3b16b4d3cb563f12e8fb3a9b9
- 出典データセット
- uspto-grants-1997_12
- 特許番号
- US05696271
反応ノート
読み込み中…