Glycine → HCID 178446845、化合物

HRID 1939643

反応式

HRID 1939643 の反応式
[NH2:1][CH2:2][C:3]([OH:5])=[O:4].[OH-].[Na+].[C:8](=[NH:15])(OC)[CH2:9][CH2:10][CH2:11][CH3:12]>CO.O.C1(C)C=CC=CC=1>[C:8]([NH:1][CH2:2][C:3]([OH:5])=[O:4])(=[NH:15])[CH2:9][CH2:10][CH2:11][CH3:12]

参加物

7

反応物 3

HCID 750GlycineHCID 14798Sodium HydroxideHCID 5743466Methyl pentanimidate

生成物 1

HCID 178446845HCID 178446845、化合物

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 962Water溶媒HCID 1140Toluene溶媒

反応条件

温度
0 °C

実験手順

A stirred suspension of glycine (18.77 g, 0.25 mol) in methanol (80 ml) and water (4.5 ml) was cooled to 0° C. and adjusted to pH 9.6 by adding 30 percent strength sodium hydroxide solution. Methyl pentanimidate (68.81 g of a 42 percent strength solution in toluene=0.25 mol) was added to this suspension over the course of 5 minutes. After stirring for 18 hours at room temperature, the suspension was filtered, and the filter cake was washed with toluene (75 ml) and dried. The yield of the title compound was 25.45 g (purity>95 percent by H-NMR), 64 percent based on glycine. Other data concerning the title compound was:

後処理

  1. filtrationthe suspension was filtered
  2. washthe filter cake was washed with toluene (75 ml)
  3. customdried

出典と根拠

ORDレコード
ord-29a4371eaa2e4314b849bb321c42dbc2
出典データセット
uspto-grants-1997_12
特許番号
US05696272

関連ノート

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