7-(Trifluoroacetylamino)-2,3-dihydrobenzofuran → 2,3-Dihydro-1-benzofuran-7-amine

HRID 1940592ノート

反応式

HRID 1940592 の反応式
FC(F)(F)C([NH:5][C:6]1[C:14]2[O:13][CH2:12][CH2:11][C:10]=2[CH:9]=[CH:8][CH:7]=1)=O>CO.[OH-].[Na+]>[NH2:5][C:6]1[C:14]2[O:13][CH2:12][CH2:11][C:10]=2[CH:9]=[CH:8][CH:7]=1

参加物

4

反応物 1

HCID 214634927-(Trifluoroacetylamino)-2,3-dihydrobenzofuran

生成物 1

HCID 128059502,3-Dihydro-1-benzofuran-7-amine収率 96.2%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

A solution of 7-(trifluoroacetylamino)-2,3-dihydrobenzofuran (D2) (1.6 g) in methanol (30 ml) and 10% NaOH (3 ml) was heated to reflux for 24h. The mixture was evaporated under reduced pressure and partitioned between ethyl acetate and water. The organic phase was dried (Na2SO4) and the solvent evaporated under reduced pressure to give the title compound (900 mg, 96%) as a pale orange oil, which crystallised on standing.

後処理

  1. temperatureto reflux for 24h
  2. customThe mixture was evaporated under reduced pressure
  3. custompartitioned between ethyl acetate and water
  4. dry with materialThe organic phase was dried (Na2SO4)
  5. customthe solvent evaporated under reduced pressure

出典と根拠

ORDレコード
ord-8a7f6292877d4ba6b73be4be91a8a92f
出典データセット
uspto-grants-1997_12
特許番号
US05700818

反応ノート

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