Methanol → 3-(4,5,7-Trifluorobenzothiazol-2-yl)propionic acid

HRID 1940609

反応式

HRID 1940609 の反応式
CO.[OH-].[Na+].[F:5][C:6]1[C:11]2[N:12]=[C:13]([CH2:15][CH2:16][C:17]([O:19]CC)=[O:18])[S:14][C:10]=2[C:9]([F:22])=[CH:8][C:7]=1[F:23]>O>[F:5][C:6]1[C:11]2[N:12]=[C:13]([CH2:15][CH2:16][C:17]([OH:19])=[O:18])[S:14][C:10]=2[C:9]([F:22])=[CH:8][C:7]=1[F:23]

参加物

5

反応物 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 21463563HCID 21463563、化合物

生成物 1

HCID 214635293-(4,5,7-Trifluorobenzothiazol-2-yl)propionic acid収率 85%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

To a mixture of methanol (8 ml), water (6 ml) and 2N sodium hydroxide (2 ml, 4 mmol) was added ethyl 3-(4,5,7-trifluorobenzothiazol-2-yl)propionate (1.1 g, 3.8 mmol) and the mixture was stirred for 15 min. at ambient temperature. The reaction solution was diluted with water and then extracted with ethyl acetate. The organic layer was washed with water, then dried and evaporated to yield a residue, which was recrystallized from hexane-isopropyl ether to give 3-(4,5,7-trifluorobenzothiazol-2-yl)propionic acid (840 mg, 85%) as colorless needles.

後処理

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. customdried
  4. customevaporated
  5. customto yield a residue, which
  6. customwas recrystallized from hexane-isopropyl ether

出典と根拠

ORDレコード
ord-ce24b89938924a28b11bba22ecc063e1
出典データセット
uspto-grants-1997_12
特許番号
US05700819

関連ノート

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