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2-Furanacrylic acid → (E)-N-[3-((R)-2-Amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-3-furan-2-yl-acrylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Furanacrylic acid | HCID 643402 | — |
| 反応物 | (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine | HCID 58304207 | — |
| 生成物 | (E)-N-[3-((R)-2-Amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-3-furan-2-yl-acrylamide | HCID 53241493 | — |
反応手順
The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and (E)-3-furan-2-yl-acrylic acid following procedure I yielded the title compound after purification by preparative HPLC. MS (ISP): m/z=380.1 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08389513B2 |
| 出典データセット | uspto-grants-2013_03 |
| ORD ID | ord-679dabe590e34c1490aff359c9d48cea |
| 出典メモ | uspto-grants-2013_03 |