Potassium Carbonate → N-(4-hydroxybutyl)benzothiazole-2-carboxamide

HRID 1942382ノート

反応式

HRID 1942382 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10](Cl)=[O:11].[NH2:13][CH2:14][CH2:15][CH2:16][CH2:17][OH:18].C([O-])([O-])=O.[K+].[K+]>C(#N)C>[OH:18][CH2:17][CH2:16][CH2:15][CH2:14][NH:13][C:10]([C:2]1[S:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=1)=[O:11]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 258684-Amino-1-butanolHCID 2776254Benzothiazole-2-carbonyl chloride

生成物 1

HCID 66937473N-(4-hydroxybutyl)benzothiazole-2-carboxamide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

1 g (5 mmol) benzothiazol-2-carbonyl chloride, 542 mg (6 mmol) 4-aminobutan-1-ol and 1.4 g (10 mmol) K2CO3 in acetonitrile is stirred for three days at room temperature. The solvent is evaporated and the product is dissolved in ethyl acetate and washed with 2N HCl and water. After evaporation of the solvent the yellow semisolid is crystallized from ethyl acetate.

後処理

  1. customThe solvent is evaporated
  2. dissolutionthe product is dissolved in ethyl acetate
  3. washwashed with 2N HCl and water
  4. customAfter evaporation of the solvent the yellow semisolid
  5. customis crystallized from ethyl acetate

出典と根拠

ORDレコード
ord-9ce5a60c887c4de9a7f58f32a483d012
出典データセット
uspto-grants-2013_03
特許番号
US08389555B2

反応ノート

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