Triethylamine → N-(4,4-diethoxybutyl)-4-phenylpiperidine-1-carboxamide

HRID 1942388

反応式

HRID 1942388 の反応式
[C:1]1([CH:7]2[CH2:12][CH2:11][N:10]([C:13](Cl)=[O:14])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:16]([O:18][CH:19]([O:24][CH2:25][CH3:26])[CH2:20][CH2:21][CH2:22][NH2:23])[CH3:17].C(N(CC)CC)C.C(=O)([O-])[O-].[Na+].[Na+]>ClCCl>[CH2:25]([O:24][CH:19]([O:18][CH2:16][CH3:17])[CH2:20][CH2:21][CH2:22][NH:23][C:13]([N:10]1[CH2:11][CH2:12][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][CH2:9]1)=[O:14])[CH3:26]

参加物

6

反応物 4

HCID 8471TriethylamineHCID 10340Sodium CarbonateHCID 806724,4-DiethoxybutylamineHCID 866513114-Phenylpiperidine-1-carbonyl chloride

生成物 1

HCID 66937642N-(4,4-diethoxybutyl)-4-phenylpiperidine-1-carboxamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 895 mg (4 mmol) of 4-phenylpiperidine-1-carbonylchloride in 4 mL dichloromethane is added to 0.69 mL (4 mmol) 4,4-diethoxybutylamine and 1.68 mL (12 mmol) of triethylamine dissolved in 20 mL of dichloromethane. The mixture is stirred overnight. 20 mL of saturated sodium carbonate solution is added. The organic phase is separated, dried with sodium sulfate and the solvent evaporated.

後処理

  1. customThe organic phase is separated
  2. dry with materialdried with sodium sulfate
  3. customthe solvent evaporated

出典と根拠

ORDレコード
ord-7751316ceb004643bc0cc65ccacf0998
出典データセット
uspto-grants-2013_03
特許番号
US08389555B2

関連ノート

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