Water → 4-{[Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amino]-methyl}-benzoic acid

HRID 1942397ノート

反応式

HRID 1942397 の反応式
C[O:2][C:3](=[O:24])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]([CH2:21][CH2:22][CH3:23])[CH:12]2[CH2:20][CH2:19][C:15]3[N:16]=[CH:17][S:18][C:14]=3[CH2:13]2)=[CH:6][CH:5]=1.[OH-].[Na+].O>C(O)(=O)C>[CH2:21]([N:11]([CH2:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([OH:24])=[O:2])=[CH:9][CH:8]=1)[CH:12]1[CH2:20][CH2:19][C:15]2[N:16]=[CH:17][S:18][C:14]=2[CH2:13]1)[CH2:22][CH3:23]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 866513134-{[Propyl-(4,5,6,7-tetrahydrobenzothiazol-6-yl)amino]methyl}benzoic acid methylester

生成物 1

HCID 669374084-{[Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amino]-methyl}-benzoic acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
80 °C

実験手順

A mixture of 1.93 g (5.6 mmol) 42A, 840 mg (21 mmol) sodium hydroxide and 25 mL water is stirred for 4 hours at 80° C. The mixture is allowed to cool to room temperature and then neutralized with acetic acid and extracted three times with dichloromethane. The combined organic fractions are dried with sodium sulfate, and the solvent is evaporated in vacuum.

後処理

  1. temperatureto cool to room temperature
  2. extractionextracted three times with dichloromethane
  3. dry with materialThe combined organic fractions are dried with sodium sulfate
  4. customthe solvent is evaporated in vacuum

出典と根拠

ORDレコード
ord-7c877cc7518746599f23fd706423cb06
出典データセット
uspto-grants-2013_03
特許番号
US08389555B2

反応ノート

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