Phenol → (2,2-Diethoxyethoxy)benzene

HRID 1942440

反応式

HRID 1942440 の反応式
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:8]([O:10][CH:11]([O:14][CH2:15][CH3:16])[CH2:12]Cl)[CH3:9].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>[OH-].[Na+].CN(C)C=O>[CH2:8]([O:10][CH:11]([O:14][CH2:15][CH3:16])[CH2:12][O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:9]

参加物

7

反応物 4

HCID 996PhenolHCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 121282-Chloro-1,1-diethoxyethane

生成物 1

HCID 96328(2,2-Diethoxyethoxy)benzene

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

0.94 g (10 mmol) of phenol, 1.52 g (10 mmol) of chloroacetaldehyde diethyl acetal, 2.77 g (20 mmol) of potassium carbonate, 500 mg of potassium iodide and 5 ml of dimethylformamide were heated for 1 hour at 175° C. under microwave conditions. The mixture was then diluted with 2M aqueous sodium hydroxide solution and extracted with dichloromethane. The organic layer was dried with sodium sulfate and the solvent evaporated in vacuum. The crude product was obtained in almost quantitative yield.

後処理

  1. extractionextracted with dichloromethane
  2. dry with materialThe organic layer was dried with sodium sulfate
  3. customthe solvent evaporated in vacuum

出典と根拠

ORDレコード
ord-907d57b1e0434595b23a759968da1805
出典データセット
uspto-grants-2013_03
特許番号
US08389555B2

関連ノート

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