Cesium carbonate → 2-[4-[(1-Methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3-thiazole

HRID 1942638ノート

反応式

HRID 1942638 の反応式
CC1(C)C(C)(C)OB([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH:16]([CH3:18])[CH3:17])=[C:11]([C:19]([F:22])([F:21])[F:20])[CH:10]=2)O1.Br[C:25]1[S:26][CH:27]=[CH:28][N:29]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>C(#N)C.O.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].C(Cl)Cl>[CH3:18][CH:16]([O:15][C:12]1[CH:13]=[CH:14][C:9]([C:25]2[S:26][CH:27]=[CH:28][N:29]=2)=[CH:10][C:11]=1[C:19]([F:20])([F:21])[F:22])[CH3:17]

参加物

7

反応物 3

HCID 10796Cesium carbonateHCID 764302-BromothiazoleHCID 58494057HCID 58494057、化合物

生成物 1

HCID 669822262-[4-[(1-Methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3-thiazole収率 52.4%

試薬・触媒・溶媒 3

HCID 178418807HCID 178418807、化合物触媒HCID 962Water溶媒HCID 6342Acetonitrile溶媒

反応条件

温度
120 °C

実験手順

To a solution of 4,4,5,5-tetramethyl-2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane (D42) (160 mg), 2-bromo-1,3-thiazole (119 mg) and cesium carbonate (237 mg) in acetonitrile (15 mL) and water (3.75 mL) stirred under nitrogen at room temperature was added PdCl2(dppf)-CH2Cl2 adduct (39.6 mg) in one charge. The reaction vessel was sealed and heated under microwave at 120° C. for 1 h. After cooling the reaction, the reaction mixture was filtered and the filtrate was partitioned between ethyl acetate (150 mL) and saturated brine (50 mL). The organic phase was dried over sodium sulphate and evaporated in vacuo. The crude product was purified by column chromatography to give 2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3-thiazole (D66) (73 mg). MS (ES): C13H12F3NOS requires 287. found 288.1 (M+H+).

後処理

  1. additioncharge
  2. customThe reaction vessel was sealed
  3. temperatureAfter cooling
  4. customthe reaction
  5. filtrationthe reaction mixture was filtered
  6. customthe filtrate was partitioned between ethyl acetate (150 mL) and saturated brine (50 mL)
  7. dry with materialThe organic phase was dried over sodium sulphate
  8. customevaporated in vacuo
  9. customThe crude product was purified by column chromatography

出典と根拠

ORDレコード
ord-1f070925888b4a18a0544574ccb23e57
出典データセット
uspto-grants-2013_03
特許番号
US08389508B2

反応ノート

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