Hydrochloric Acid → HCID 58494135、化合物
反応式
[Cl:1][C:2]1[C:3]([O:25][CH:26]([CH3:28])[CH3:27])=[N:4][CH:5]=[C:6]([C:8]2[S:12][N:11]=[C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15](/[CH:19]=[CH:20]/[O:21]C)[C:14]=3[CH2:23][CH3:24])[N:9]=2)[CH:7]=1.Cl>O1CCCC1>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[S:12][N:11]=[C:10]([C:13]3[C:14]([CH2:23][CH3:24])=[C:15]([CH2:19][CH:20]=[O:21])[CH:16]=[CH:17][CH:18]=3)[N:9]=2)[CH:5]=[N:4][C:3]=1[O:25][CH:26]([CH3:28])[CH3:27]参加物
4
反応条件
- 温度
- 70 °C
実験手順
To a solution of 3-chloro-5-(3-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,2,4-thiadiazol-5-yl)-2-[(1-methylethyl)oxy]pyridine (D110) (2 g, 4.81 mmol) in Tetrahydrofuran (50 mL) was added HCl (4.81 mL, 9.62 mmol). The resulted solution was heated to 70° C. for 2 h. THF was removed in vacuo to afford [3-(5-{5-chloro-6-[(1-methylethyl)oxy]-3-pyridinyl}-1,2,4-thiadiazol-3-yl)-2-ethylphenyl]acetaldehyde (D111) (2 g, 4.98 mmol, 103% yield) as a crude product, which was used directly without further purification. MS (ES): C20H20ClN3O2S requires 401.0. found 402.0 (M+H+).