Sodium borohydride → (3-Bromo-2-ethylphenyl)methanol
反応式
[Br:1][C:2]1[C:3]([CH2:10][CH3:11])=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[BH4-].[Na+]>CO>[Br:1][C:2]1[C:3]([CH2:10][CH3:11])=[C:4]([CH2:5][OH:6])[CH:7]=[CH:8][CH:9]=1参加物
4
実験手順
To a solution of 3-bromo-2-ethylbenzaldehyde (5 g, 23.47 mmol) in Methanol (50 mL) was added NaBH4 (1.776 g, 46.9 mmol) at 0° C. The reaction solution was stirred at room temperature for 2 hours. The solvent was removed in vacuo and the residue was dissolved in ethyl acetate, washed with water, dried over sodium sulphate, concentrated and purified by ISCO column chromatography to afford (3-bromo-2-ethylphenyl)methanol (D133) (3 g) as an oil. MS (ES): C9H11BrO requires 213.99. found 197.0 (M+H+-18).
後処理
- customThe solvent was removed in vacuo
- dissolutionthe residue was dissolved in ethyl acetate
- washwashed with water
- dry with materialdried over sodium sulphate
- concentrationconcentrated
- custompurified by ISCO column chromatography
出典と根拠
- ORDレコード
- ord-52b5562d3a404dc19a1d7688650a783c
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08389508B2
反応ノート
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