Hydrochloric Acid → HCID 57506022、化合物
反応式
[Br:1][C:2]1[C:3]([CH2:14][CH3:15])=[C:4]([CH:8]([OH:13])S([O-])(=O)=O)[CH:5]=[CH:6][CH:7]=1.Cl>C1COCC1>[Br:1][C:2]1[C:3]([CH2:14][CH3:15])=[C:4]([CH:5]=[CH:6][CH:7]=1)[CH:8]=[O:13]参加物
4
実験手順
To a solution of (3-bromo-2-ethylphenyl)(hydroxy)methanesulfonate (5.26 g, 16.59 mmol) in THF (25 mL) was added HCl (16.59 mL, 49.8 mmol). The mixture was stirred for an hour at rt. THF was removed under the reduced pressure. Residue was dissolved in EtOAc (50 mL) then washed with brine (10 mL). The organic phase was dried over anhydrous sodium sulfate, concentrated under the reduced pressure and dried in vacuum to give 3-bromo-2-ethylbenzaldehyde (2.89 g) as pale yellow oil.
後処理
- customTHF was removed under the reduced pressure
- dissolutionResidue was dissolved in EtOAc (50 mL)
- washthen washed with brine (10 mL)
- dry with materialThe organic phase was dried over anhydrous sodium sulfate
- concentrationconcentrated under the reduced pressure
- customdried in vacuum
出典と根拠
- ORDレコード
- ord-0775f863844649ca90bc5f08c8c246d7
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08389508B2
反応ノート
読み込み中…