Methanol → Propanoic acid, 2-bromo-3-(phenylmethoxy)-, methyl ester

HRID 1943142ノート

反応式

HRID 1943142 の反応式
[Br:1][CH:2]([CH2:6][O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]([OH:5])=[O:4].S(Cl)(Cl)=O.[CH3:19]O>>[Br:1][CH:2]([CH2:6][O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]([O:5][CH3:19])=[O:4]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 109562653-(Benzyloxy)-2-bromopropanoic acid

生成物 1

HCID 11011152Propanoic acid, 2-bromo-3-(phenylmethoxy)-, methyl ester収率 99%

実験手順

A solution of 2-bromo-3-[(phenylmethyl)oxy]propanoic acid (6 g, 23.2 mmol) in methanol (40 ml) at rt under argon was treated with thionyl chloride (1.7 ml, 23.2 mmol) and the reaction was then stirred at rt for 3 h and then evaporated to give product as a yellow oil (6.3 g, 99%).

後処理

  1. customevaporated

出典と根拠

ORDレコード
ord-c81117c412504c65aeee6c5632869be6
出典データセット
uspto-grants-2013_03
特許番号
US08389524B2

反応ノート

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