Trifluoroacetic acid → (R)-2-Amino-3-cyclohexylpropanoic acid trifluoroacetate

HRID 1943297ノート

反応式

HRID 1943297 の反応式
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].C([NH:15][C@H:16]([CH2:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)[C:17]([OH:19])=[O:18])(OC(C)(C)C)=O>C(Cl)Cl>[F:4][C:3]([F:6])([F:5])[C:1]([OH:7])=[O:2].[NH2:15][C@H:16]([CH2:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)[C:17]([OH:19])=[O:18]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 2755927(2R)-2-{[(tert-butoxy)carbonyl]amino}-3-cyclohexylpropanoic acid

生成物 1

HCID 68547671(R)-2-Amino-3-cyclohexylpropanoic acid trifluoroacetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

5 ml of TFA were added to a solution of (R)-N-Boc-2-amino-3-cyclohexylpropanoic acid (3.0 g, 11.1 mmol) in 20 ml of CH2Cl2, and the mixture was stirred at RT overnight. After deprotection was complete, the CH2Cl2 was evaporated off, and the remaining solid was mixed with 50 ml of H2O and lyophilized. Yield: 2.84 g (90%) of (R)-2-amino-3-cyclohexylpropanoic acid trifluoroacetate as colorless solid.

後処理

  1. customthe CH2Cl2 was evaporated off
  2. additionthe remaining solid was mixed with 50 ml of H2O

出典と根拠

ORDレコード
ord-e1635b8dee454b27a6afff92f3283f61
出典データセット
uspto-grants-2013_03
特許番号
US08389764B2

反応ノート

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