Sodium Hydroxide → HCID 59184940、化合物
反応式
[O:1]=[C:2]([C@@:18]1([OH:59])[CH2:35][C@H:34]([O:36][C@@H:37]2[O:51][C@@H:50]([CH3:52])[C@H:40]3[O:41][C@H:42]4[N:47]([C@H:39]3[CH2:38]2)[CH2:46][CH2:45][O:44][C@@H:43]4[O:48][CH3:49])[C:33]2[C:20](=[C:21]([OH:58])[C:22]3[C:23](=[O:57])[C:24]4[C:29]([C:30](=[O:54])[C:31]=3[C:32]=2[OH:53])=[C:28]([O:55][CH3:56])[CH:27]=[CH:26][CH:25]=4)[CH2:19]1)[CH2:3][O:4][C:5]1([O:11][CH2:12][C:13]([O:15]CC)=[O:14])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1.[OH-].[Na+]>O.C(O)(=O)C>[O:1]=[C:2]([C@@:18]1([OH:59])[CH2:35][C@H:34]([O:36][C@@H:37]2[O:51][C@@H:50]([CH3:52])[C@H:40]3[O:41][C@H:42]4[N:47]([C@H:39]3[CH2:38]2)[CH2:46][CH2:45][O:44][C@@H:43]4[O:48][CH3:49])[C:33]2[C:20](=[C:21]([OH:58])[C:22]3[C:23](=[O:57])[C:24]4[C:29]([C:30](=[O:54])[C:31]=3[C:32]=2[OH:53])=[C:28]([O:55][CH3:56])[CH:27]=[CH:26][CH:25]=4)[CH2:19]1)[CH2:3][O:4][C:5]1([O:11][CH2:12][C:13]([OH:15])=[O:14])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1参加物
4
反応条件
- 温度
- 5 °C
実験手順
To 30 mg of 45, 5 mL of in 01N NaOH was added. The suspension was cooled at 5° C. and stirred under argon for 3 hours. The aqueous solution was brought to pH≅8 with 10% acetic acid water solution and extracted with dichloromethane (2×10 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered, the solvent removed under vacuum and the residue purified by flash chromatography (DCM/MeOH 90:10) to give 5 mg (y=8% 2 steps) of the acid intermediate 46 as a red solid. MS (ESI): 798 [M+H]+. Retention time=3.94 min. Method 2