4-Bromophenacyl bromide → 2-azido-1-(4-bromophenyl)ethanone
反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=[O:4].[N-:12]=[N+:13]=[N-:14].[Na+]>CO>[N:12]([CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=[O:4])=[N+:13]=[N-:14]参加物
4
実験手順
A solution of 2,4′-dibromoacetophenone (1.390 g, 5.0 mmol) in MeOH (10 mL) was poured over 10 mL of an aqueous solution of sodium azide (0.325 g, 5.00 mmol) in an ice bath. The mixture was stirred at room temperature for 18 hours. The solvent was removed and then extracted with ethyl ether (20 mL) and water (20 mL). The organic layer was dried over MgSO4 and concentrated in vacuo to obtain 2-azido 4′-bromoacetophenone (1.0 g, 4.17 mmol, 83% yield). 1H NMR (CDCl3) 5.45 (s, 2H), 7.67 (d, J=8.4 Hz, 2H), 7.79 (d, J=8.4 Hz, 2H) ppm.
後処理
- customThe solvent was removed
- extractionextracted with ethyl ether (20 mL) and water (20 mL)
- dry with materialThe organic layer was dried over MgSO4
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-c913f17f6b9e443bada90e6eade854b3
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08394742B2
反応ノート
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