Hydrochloric Acid → HCID 178527757、化合物
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([NH2:8])[CH:7]=1.CCO[C:13]([S-:15])=[S:14].[K+].Cl>O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[S:14][C:13]([SH:15])=[N:8][C:6]=2[CH:7]=1参加物
5
反応条件
- 温度
- 140 °C
実験手順
To a solution of 5-bromo-2-fluorobenzenamine (200 mg, 1.28 mmol) in N-methyl-2-pyrrolidine (1.5 mL) was added potassium o-ethyl carbonodithioate (410 mg, 2.56 mmol). The mixture was heated at 140° C. for 2 h. The reaction mixture was poured into a large amount of water, acidified with concentrated hydrochloric acid, and filtered to give 5-bromo-benzothiazole-2-thiol 300 mg (95%).
後処理
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-eafcaf284cb44ca59592d8346d056bc4
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08394842B2
反応ノート
読み込み中…