Trifluoroacetic acid → HCID 59264546、化合物

HRID 1944717ノート

反応式

HRID 1944717 の反応式
[CH3:1][O:2][CH2:3][CH2:4][C@@H:5]([NH:12]C(=O)OC(C)(C)C)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][O:2][CH2:3][CH2:4][C@H:5]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[NH2:12]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 57791175HCID 57791175、化合物2 回

生成物 1

HCID 59264546HCID 59264546、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(R)-tert-Butyl 3-methoxy-1-phenylpropylcarbamate (Intermediate 61, 78 mg, 0.294 mmol) was dissolved in DCM (4.5 ml) and TFA (0.5 ml) was added. The reaction mixture was stirred for 1 h at room temperature when LCMS indicated that the reaction was complete. The reaction mixture was concentrated in vacuo, and the crude product was taken onto next step without further purification (0.294 mmol). LCMS [M+H]=166

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe crude product was taken onto next step without further purification (0.294 mmol)

出典と根拠

ORDレコード
ord-d4c43da7970f4d3297495ebb8685d3c2
出典データセット
uspto-grants-2013_03
特許番号
US08394858B2

反応ノート

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