1-Benzyl-4-((6-((tert-butyldimethylsilyl)oxy)hexyl)oxy)piperidine → HCID 58505168、化合物

HRID 1944858ノート

反応式

HRID 1944858 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[Si:22]([O:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][O:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23]

参加物

5

反応物 2

HCID 575169301-Benzyl-4-((6-((tert-butyldimethylsilyl)oxy)hexyl)oxy)piperidineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 58505168HCID 58505168、化合物収率 98.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Intermediate 22 (157 mg, 0.387 mmol) was dissolved in MeOH (5 mL) then added 10% (w/w) Pd/C (41 mg, 0.0387 mmol). The reaction vessel was attached to 3-way valve with balloon containing hydrogen gas. The vessel was evacuated 3 times then back flushed with hydrogen. The resulting suspension was stirred overnight, filtered, and concentrated to give the title compound (120 mg) as clear oil. The compound was used with no further purification. ES/MS calcd for C17H38NO2Si+ 316.3. Found m/z=316.3 (M+H)+.

後処理

  1. customThe reaction vessel was attached to 3-way valve with balloon
  2. customThe vessel was evacuated 3 times
  3. customthen back flushed with hydrogen
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-3fbf310c0dfe43c58cab7d547eaeb997
出典データセット
uspto-grants-2013_03
特許番号
US08394829B2

反応ノート

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