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Acetic Acid → (R)-6-[[3-[[8-[[2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

HRID 1944975
ノート
印刷プレビュー

反応式

HRID 1944975 の反応式
CCCC[N+](CCCC)(CCCC)CCCC.[F-].[Si]([O:26][C@H:27]([C:73]1[CH:82]=[CH:81][C:80]([OH:83])=[C:79]2[C:74]=1[CH:75]=[CH:76][C:77](=[O:84])[NH:78]2)[CH2:28][NH:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][NH:38][C:39]([C:41]1[CH:42]=[C:43]([S:47]([C:50]2[CH:51]=[C:52]3[C:57](=[C:58]([CH3:60])[CH:59]=2)[N:56]=[CH:55][C:54]([C:61]([NH2:63])=[O:62])=[C:53]3[NH:64][C:65]2[CH:70]=[CH:69][CH:68]=[C:67]([O:71][CH3:72])[CH:66]=2)(=[O:49])=[O:48])[CH:44]=[CH:45][CH:46]=1)=[O:40])(C(C)(C)C)(C)C.C(O)(=O)C>C1COCC1>[OH:26][C@H:27]([C:73]1[CH:82]=[CH:81][C:80]([OH:83])=[C:79]2[C:74]=1[CH:75]=[CH:76][C:77](=[O:84])[NH:78]2)[CH2:28][NH:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][NH:38][C:39]([C:41]1[CH:42]=[C:43]([S:47]([C:50]2[CH:51]=[C:52]3[C:57](=[C:58]([CH3:60])[CH:59]=2)[N:56]=[CH:55][C:54]([C:61]([NH2:63])=[O:62])=[C:53]3[NH:64][C:65]2[CH:70]=[CH:69][CH:68]=[C:67]([O:71][CH3:72])[CH:66]=2)(=[O:48])=[O:49])[CH:44]=[CH:45][CH:46]=1)=[O:40]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 176Acetic AcidHCID 2724141Tetrabutylammonium FluorideHCID 86659116(R)-6-[[3-[[8-[[2-[(tert-Butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl]ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

生成物 1

HCID 54588137(R)-6-[[3-[[8-[[2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide
収率 28.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of TBAF (1.0 M in THF, 0.244 mL, 0.244 mmol) was added to a stirring solution of Intermediate 148 (76 mg, 0.0813 mmol) in THF (2 mL) at rt. After stirring over night, glacial acetic acid (0.023 mL, 0.407 mmol) was added and stirred for an additional 16 h. The reaction mixture was concentrated and purified by PREP-HPLC to give the title compound (19 mg).

後処理

  1. stirringstirred for an additional 16 h
  2. concentrationThe reaction mixture was concentrated
  3. custompurified by PREP-HPLC

出典と根拠

ORDレコード
ord-7529d12907a94d68b063a7911ae51904
出典データセット
uspto-grants-2013_03
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08394829B2

反応ノート

読み込み中…

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