6-Bromo-3-hydroxy-3-methylindolin-2-one → 6-Bromo-3-methyl-1H-indole
反応式
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](O)([CH3:12])[C:7](=O)[NH:8]2)=[CH:4][CH:3]=1>C1COCC1>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1参加物
3
反応条件
- 温度
- 60 °C
実験手順
A mixture of 6-bromo-3-hydroxy-3-methyl-1,3-dihydro-2H-indol-2-one (0.25 g, 1.0 mmol) and BH3—S(CH3)2 (5.16 mL. 1.0 M, 5.16 mmol) in THF (20 mL) was heated at 60° C. The reaction was quenched with MeOH. Volatiles were removed. Chromatography over silica eluting with 4:1 hexane:EtOAc afforded the title compound. LC-MS: calculated for C9H8BrN 210.07, observed m/e 211.0 (M+H)+ (Rt 1.14 min).
後処理
- customThe reaction was quenched with MeOH
- customVolatiles were removed
出典と根拠
- ORDレコード
- ord-2ee3f0f0f59e4f0cb6e0e963e2e83055
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08394969B2
反応ノート
読み込み中…