tert-Butyl ((1-benzylpiperidin-4-yl)methyl)carbamate → Tert-butyl (piperidin-4-ylmethyl)carbamate

HRID 19464

反応式

HRID 19464 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[C:19]([O:18][C:16]([NH:15][CH2:14][CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:17])([CH3:22])([CH3:20])[CH3:21]

参加物

5

反応物 2

HCID 2824066tert-Butyl ((1-benzylpiperidin-4-yl)methyl)carbamateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 723429Tert-butyl (piperidin-4-ylmethyl)carbamate収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 1-benzyl-4-tertbutyloxycarbonylaminomethylpiperidine 8 (4.79 g; 15.7 mmol) in 120 ml of MeOH is poured into a hydrogenation reactor. The 10% Pd/C-based catalyst is added (0.872 g; 0.82 mmol) and the mixture is subjected to a hydrogen pressure of 3.5 bars (50 psi) for 24 hours in a Parr type shaker. After filtration on celite and washing with methanol, the medium is concentrated in order to produce 3.36 g (Yield=100%) of product in the form of white crystals.

後処理

  1. additionis added (0.872 g; 0.82 mmol)
  2. filtrationAfter filtration on celite
  3. washwashing with methanol
  4. concentrationthe medium is concentrated in order

出典と根拠

ORDレコード
ord-389f564054af4404af46e958b7bcb7da
出典データセット
uspto-grants-2010_06
特許番号
US07745413B2

関連ノート

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