Ethylamine → HCID 23028136、化合物
反応式
[Cl:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7](Cl)=[N:6][N:5]2[C:11]=1[S:12]([NH2:15])(=[O:14])=[O:13].[CH2:16]([NH2:18])[CH3:17]>C(#N)C>[Cl:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([NH:18][CH2:16][CH3:17])=[N:6][N:5]2[C:11]=1[S:12]([NH2:15])(=[O:14])=[O:13]参加物
4
実験手順
2,6-Dichloroimidazo[1,2-b]pyridazin-3-ylsulfonamide (2.00 g, 7.50 mmol) and ethylamine (50%, 10.0 ml) were stirred in acetonitrile (100 ml) at 70° C. for 8 hours. The reaction mixture was concentrated to dryness, dissolved in ice-water (50.0 ml), and adjusted to pH 6 with conc. hydrochloric acid. The precipitated crystals were filtered and washed with water to give the title compound as pale yellow crystals. The yield was 1.10 g (53.3%).
後処理
- concentrationThe reaction mixture was concentrated to dryness
- dissolutiondissolved in ice-water (50.0 ml)
- filtrationThe precipitated crystals were filtered
- washwashed with water
出典と根拠
- ORDレコード
- ord-f9d7484b3602446bb993a611cbe366d8
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08399381B2
反応ノート
読み込み中…