2-(1-methylethyl)cyclohepta[d]imidazol-4(1H)-one → 2-(1-methylethyl)-5,6,7,8-tetrahydrocyclohepta[d]imidazol-4(1H)-one
反応式
[CH3:1][CH:2]([C:4]1[NH:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:13](=[O:14])[C:6]=2[N:5]=1)[CH3:3]>CO.[Pd]>[CH3:3][CH:2]([C:4]1[NH:8][C:7]2[CH2:9][CH2:10][CH2:11][CH2:12][C:13](=[O:14])[C:6]=2[N:5]=1)[CH3:1]参加物
4
実験手順
A solution of Intermediate 1 (3.4 g) in methanol (700 mL) was hydrogenated using the H-Cube (settings: room temp, 1.4 ml/min flow rate) and 10% Pd/C CatCart 30 as the catalyst. The solvent was concentrated under vacuum to give the title compound (3.5 g). LC/MS MH+ 193, Rt 0.42 min (2 minute run).
後処理
- concentrationThe solvent was concentrated under vacuum
出典と根拠
- ORDレコード
- ord-f32e9b7499154f05b514594c08511f4f
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08399444B2
反応ノート
読み込み中…