2-(1,1-dimethylethyl)cyclohepta[d]imidazol-4(1H)-one → 2-(1,1-dimethylethyl)-5,6,7,8-tetrahydrocyclohepta[d]imidazol-4(1H)-one

HRID 1946479ノート

反応式

HRID 1946479 の反応式
[CH3:1][C:2]([C:5]1[NH:9][C:8]2[CH:10]=[CH:11][CH:12]=[CH:13][C:14](=[O:15])[C:7]=2[N:6]=1)([CH3:4])[CH3:3]>CO.[Pd]>[CH3:4][C:2]([C:5]1[NH:9][C:8]2[CH2:10][CH2:11][CH2:12][CH2:13][C:14](=[O:15])[C:7]=2[N:6]=1)([CH3:1])[CH3:3]

参加物

4

反応物 1

HCID 584602322-(1,1-dimethylethyl)cyclohepta[d]imidazol-4(1H)-one

生成物 1

HCID 584601622-(1,1-dimethylethyl)-5,6,7,8-tetrahydrocyclohepta[d]imidazol-4(1H)-one収率 87.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of Intermediate 63 (1.9 g) in methanol (400 mL) was hydrogenated using the H-Cube (settings: room temp, 1.3 ml/min flow rate) and 10% Pd/C CatCart 30 as the catalyst. The solvent was concentrated under vacuum to give the title compound (1.7 g). LC/MS MH+ 207 Rt 0.75 min (5 minute run).

後処理

  1. concentrationThe solvent was concentrated under vacuum

出典と根拠

ORDレコード
ord-f663519f2de94d9e803483f48843b53c
出典データセット
uspto-grants-2013_03
特許番号
US08399444B2

反応ノート

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