Sodium Hydroxide → Pyrido(2,3-b)(1,5)benzoxazepin-5(6H)-one
反応式
Cl[C:2]1[N:17]=[CH:16][CH:15]=[CH:14][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[OH:13])=[O:5].[OH-].[Na+]>CN(C=O)C>[N:17]1[C:2]2[O:13][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=3[NH:6][C:4](=[O:5])[C:3]=2[CH:14]=[CH:15][CH:16]=1参加物
4
反応条件
- 温度
- 130 °C
実験手順
Title compound 13 (3.65 g, 14.7 mmol) was dissolved in DMF (25.0 mL) and sodium hydroxide (0.706 g, 17.7 mmol) was added. The reaction mixture was stirred at 130° C. for 5 hours. The mixture was cooled down to room temperature and an ice/water mixture was added. The precipitate was filtered then triturated in ethanol to afford title compound 14 (1.798 g, 58%) as a white solid. LRMS (ESI): (calc) 212.06 (found) 213.2 (MH)+.
後処理
- temperatureThe mixture was cooled down to room temperature
- filtrationThe precipitate was filtered
- customthen triturated in ethanol
出典と根拠
- ORDレコード
- ord-7b43523d00224e938690083c2463b935
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08399452B2
反応ノート
読み込み中…