HCID 34176367、化合物 → 3-Phenyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine
反応式
Cl[C:2]1[C:3]2[N:4]([C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[N:9][N:10]=2)[CH:5]=[CH:6][N:7]=1.[H][H]>CCO.[Pd]>[C:11]1([C:8]2[N:4]3[CH2:5][CH2:6][NH:7][CH2:2][C:3]3=[N:10][N:9]=2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1参加物
5
実験手順
Title compound 472 (310 mg, 1.34 mmol) was dissolved in EtOH (25 mL) and 10% Pd/C (75 mg, 25% w/w) was added. The reaction mixture was stirred under 1 atmosphere of hydrogen over night. The catalyst was filtered and the filtrate was evaporated to afford title compound 473 (269 mg, 100%). MS (m/z): 201.1 (M+H).
後処理
- filtrationThe catalyst was filtered
- customthe filtrate was evaporated
出典と根拠
- ORDレコード
- ord-f7738401420a497d808327e9b6c8cb82
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08399452B2
反応ノート
読み込み中…