Isopropanol → 6-Amino-5-chloro-7-carboxy-indan-1-ol
反応式
[NH2:1][C:2]1[C:10]([C:11]#N)=[C:9]2[C:5]([CH2:6][CH2:7][CH:8]2[OH:13])=[CH:4][C:3]=1[Cl:14].[OH-:15].[Na+].C([OH:20])(C)C>>[NH2:1][C:2]1[C:10]([C:11]([OH:20])=[O:15])=[C:9]2[C:5]([CH2:6][CH2:7][CH:8]2[OH:13])=[CH:4][C:3]=1[Cl:14]参加物
4
反応条件
- 温度
- 120 °C
実験手順
A solution of the above 6-amino-5-chloro-7-cyanoindan-1-ol in isopropanol (20 ml) is treated with aqueous sodium hydroxide (380 mg in 1 ml of water) and heated at 120° C. for 15 hours. Solvent is evaporated, the residue is treated with water and washed with ethyl acetate. The aqueous layer is acidified and extracted with ethyl acetate. The separated organic layer is dried over sodium sulfate, filtered, and evaporated to give 6-amino-5-chloro-7-carboxy-indan-1-ol which is directly used in the next step. LC/MS: 228/230 (M+1)+.