Thionyl Chloride → 4-(Chloromethyl)-2-methoxy-1-nitrobenzene

HRID 1947800ノート

反応式

HRID 1947800 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:12]O)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10].S(Cl)([Cl:16])=O>>[Cl:16][CH2:12][C:5]1[CH:6]=[CH:7][C:8]([N+:9]([O-:11])=[O:10])=[C:3]([O:2][CH3:1])[CH:4]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 6029613-Methoxy-4-nitrobenzyl alcohol

生成物 1

HCID 220516194-(Chloromethyl)-2-methoxy-1-nitrobenzene収率 100%

実験手順

A mixture of (3-methoxy-4-nitrophenyl)methanol (0.5 g, 2.73 mmol) and thionyl chloride (0.3 mL, 4.09 mmol) was heated at reflux for 12 h. then the mixture concentrated in vacuo to afford 0.55 g of 4-(chloromethyl)-2-methoxy-1-nitrobenzene, (yield: 100% yield) which was used in further chemistries without purification.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 12 h.
  3. concentrationthe mixture concentrated in vacuo

出典と根拠

ORDレコード
ord-60946036e26a4388b1b55f83fd6328bc
出典データセット
uspto-grants-2013_03
特許番号
US08399433B2

反応ノート

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